Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50417507 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_685890 (CHEMBL1292646) | ||
| Ki | 100±n/a nM | ||
| Citation |  Tellew, JE; Lanier, M; Moorjani, M; Lin, E; Luo, Z; Slee, DH; Zhang, X; Hoare, SR; Grigoriadis, DE; St Denis, Y; Di Fabio, R; Di Modugno, E; Saunders, J; Williams, JP Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties. Bioorg Med Chem Lett20:7259-64 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
| ||
| BDBM50417507 | |||
| n/a | |||
| Name | BDBM50417507 | ||
| Synonyms: | CHEMBL1287996 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H26N6O2 | ||
| Mol. Mass. | 406.4808 | ||
| SMILES | CCC(Nc1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C)c1nnc(C)o1 |(13.26,-29.56,;14.57,-30.33,;14.57,-31.87,;15.9,-32.65,;15.88,-34.19,;14.52,-34.95,;14.51,-36.49,;13.17,-37.25,;15.84,-37.27,;17.18,-36.52,;18.64,-37.01,;19.56,-35.78,;21.1,-35.8,;18.67,-34.52,;17.2,-34.98,;19.41,-38.34,;18.64,-39.68,;19.4,-41,;20.94,-41.01,;21.71,-42.34,;23.26,-42.35,;21.72,-39.69,;20.95,-38.34,;21.72,-37.01,;13.33,-32.79,;13.35,-34.33,;11.88,-34.8,;10.97,-33.56,;9.43,-33.57,;11.86,-32.32,)| | ||
| Structure | 
| ||