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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50417509 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_685890 (CHEMBL1292646) | ||
| Ki | 79.43±n/a nM | ||
| Citation |  Tellew, JE; Lanier, M; Moorjani, M; Lin, E; Luo, Z; Slee, DH; Zhang, X; Hoare, SR; Grigoriadis, DE; St Denis, Y; Di Fabio, R; Di Modugno, E; Saunders, J; Williams, JP Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties. Bioorg Med Chem Lett20:7259-64 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50417509 | |||
| n/a | |||
| Name | BDBM50417509 | ||
| Synonyms: | CHEMBL1288026 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H26N6O2 | ||
| Mol. Mass. | 406.4808 | ||
| SMILES | COc1ccc(-c2c(C)nn3c(NC(C)Cc4noc(C)n4)cc(C)nc23)c(C)c1 |(24.48,-40.44,;22.94,-40.39,;22.2,-39.04,;20.66,-39,;19.93,-37.66,;20.73,-36.34,;19.99,-34.99,;20.87,-33.74,;22.41,-33.71,;19.94,-32.51,;18.49,-33,;17.15,-32.26,;17.12,-30.72,;15.77,-29.97,;15.72,-28.44,;14.41,-30.69,;13.19,-29.76,;13.22,-28.24,;11.77,-27.73,;10.84,-28.95,;9.31,-28.92,;11.72,-30.21,;15.81,-33.06,;15.85,-34.6,;14.53,-35.39,;17.2,-35.34,;18.52,-34.54,;22.27,-36.38,;23.07,-35.06,;23,-37.74,)| | ||
| Structure | 
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