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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50417511 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_685890 (CHEMBL1292646) | ||
| Ki | 50.12±n/a nM | ||
| Citation |  Tellew, JE; Lanier, M; Moorjani, M; Lin, E; Luo, Z; Slee, DH; Zhang, X; Hoare, SR; Grigoriadis, DE; St Denis, Y; Di Fabio, R; Di Modugno, E; Saunders, J; Williams, JP Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties. Bioorg Med Chem Lett20:7259-64 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50417511 | |||
| n/a | |||
| Name | BDBM50417511 | ||
| Synonyms: | CHEMBL1288058 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H26N6O3 | ||
| Mol. Mass. | 422.4802 | ||
| SMILES | CCC(Nc1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1OC)c1nc(C)no1 |(13.38,-27.25,;14.71,-28.02,;14.71,-29.55,;16.04,-30.32,;16.04,-31.86,;14.7,-32.64,;14.7,-34.18,;13.37,-34.95,;16.04,-34.94,;17.37,-34.18,;18.83,-34.66,;19.74,-33.41,;21.28,-33.41,;18.83,-32.16,;17.37,-32.64,;19.55,-36.02,;18.73,-37.32,;19.45,-38.68,;20.99,-38.74,;21.72,-40.1,;20.9,-41.41,;21.81,-37.42,;21.09,-36.06,;21.9,-34.75,;23.43,-34.8,;13.46,-30.44,;12.01,-29.95,;11.09,-31.18,;9.56,-31.16,;11.98,-32.43,;13.44,-31.98,)| | ||
| Structure | 
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