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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Potassium voltage-gated channel subfamily H member 2 | ||
| Ligand | BDBM50145040 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_725152 (CHEMBL1676103) | ||
| IC50 | 501.19±n/a nM | ||
| Citation |  Sinha, N; Sen, S Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. Eur J Med Chem46:618-30 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Potassium voltage-gated channel subfamily H member 2 | |||
| Name: | Potassium voltage-gated channel subfamily H member 2 | ||
| Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 126672.65 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q12809 | ||
| Residue: | 1159 | ||
| Sequence: |
| ||
| BDBM50145040 | |||
| n/a | |||
| Name | BDBM50145040 | ||
| Synonyms: | 4-[4-(3-Trifluoromethyl-phenyl)-1H-imidazol-2-yl]-cyclohexanecarboxylic acid (2-hydroxy-ethyl)-amide | CHEMBL308987 | trans-N-(2-hydroxyethyl)-4-(4-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)cyclohexanecarboxamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H22F3N3O2 | ||
| Mol. Mass. | 381.3921 | ||
| SMILES | OCCNC(=O)[C@H]1CC[C@@H](CC1)c1nc(c[nH]1)-c1cccc(c1)C(F)(F)F |r,wU:9.12,wD:6.5,(36.76,-5.11,;35.21,-5.1,;34.44,-6.44,;32.9,-6.44,;32.12,-7.78,;32.89,-9.1,;30.59,-7.77,;29.81,-6.44,;28.27,-6.44,;27.5,-7.77,;28.27,-9.1,;29.81,-9.1,;25.96,-7.78,;25,-6.58,;23.56,-7.12,;23.63,-8.63,;25.11,-9.05,;22.32,-6.22,;22.49,-4.69,;21.24,-3.78,;19.83,-4.41,;19.67,-5.94,;20.92,-6.85,;18.25,-6.56,;16.82,-7.18,;17.63,-5.14,;18.87,-7.98,)| | ||
| Structure | 
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