| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Ligand | BDBM50390127 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_834527 (CHEMBL2073576) |
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| IC50 | 3300±n/a nM |
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| Citation |  Cutshall, NS; Onrust, R; Rohde, A; Gragerov, S; Hamilton, L; Harbol, K; Shen, HR; McKee, S; Zuta, C; Gragerova, G; Florio, V; Wheeler, TN; Gage, JL Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia. Bioorg Med Chem Lett22:5595-9 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Synonyms: | PDE10_MOUSE | Pde10a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 89407.64 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1458264 |
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| Residue: | 790 |
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| Sequence: | MSNDSTEGTVGSCNATGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKTNKAKD
EPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYF
LGECNNSLCVFIPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRG
TGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQ
VQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKN
KELYSDLFDIGEEKEGKPIFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREV
DLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCAN
MYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMRFNLPARICRDIELFHFDIGPFENMW
PGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNG
LFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE
GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVI
GLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQ
LGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPGPAPSKST
PEKLNVKVED
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| BDBM50390127 |
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| n/a |
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| Name | BDBM50390127 |
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| Synonyms: | CHEMBL2069312 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21ClN2O6 |
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| Mol. Mass. | 420.844 |
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| SMILES | COC(C(=O)N\N=C\c1ccc(OC)c(OC)c1Cl)c1ccc2OCCOc2c1 |
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| Structure | 
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