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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
LigandBDBM50390149
Substrate/Competitorn/a
Meas. Tech.ChEMBL_834527 (CHEMBL2073576)
IC50 0.640000±n/a nM
Citation Cutshall, NSOnrust, RRohde, AGragerov, SHamilton, LHarbol, KShen, HRMcKee, SZuta, CGragerova, GFlorio, VWheeler, TNGage, JL Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia. Bioorg Med Chem Lett22:5595-9 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Name:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Synonyms:PDE10_MOUSE | Pde10a
Type:PROTEIN
Mol. Mass.:89407.64
Organism:Mus musculus
Description:ChEMBL_1458264
Residue:790
Sequence:
MSNDSTEGTVGSCNATGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKTNKAKD
EPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYF
LGECNNSLCVFIPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRG
TGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQ
VQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKN
KELYSDLFDIGEEKEGKPIFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREV
DLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCAN
MYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMRFNLPARICRDIELFHFDIGPFENMW
PGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNG
LFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE
GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVI
GLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQ
LGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPGPAPSKST
PEKLNVKVED
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BDBM50390149
n/a
NameBDBM50390149
Synonyms:CHEMBL2069680
TypeSmall organic molecule
Emp. Form.C22H26BrN3O5
Mol. Mass.492.363
SMILESCOC(C(=O)N\N=C\c1cc(OC)c(Br)c(OC)c1)c1ccc(cc1)N1CCOCC1
Structure
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