| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 22 member 6 |
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| Ligand | BDBM50074922 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_838299 (CHEMBL2076247) |
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| IC50 | 1500±n/a nM |
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| Citation |  Mulato, AS; Ho, ES; Cihlar, T Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther295:10-5 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 22 member 6 |
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| Name: | Solute carrier family 22 member 6 |
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| Synonyms: | OAT1 | Organic anion transporter 1 | PAH transporter | PAHT | Renal organic anion transporter 1 | S22A6_HUMAN | SLC22A6 | hOAT1 | hPAHT | hROAT1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61831.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1487359 |
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| Residue: | 563 |
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| Sequence: | MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN
GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI
VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA
FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV
AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE
GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL
QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS
IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE
LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQT
RQQQEHQKYMVPLQASAQEKNGL
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| BDBM50074922 |
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| n/a |
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| Name | BDBM50074922 |
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| Synonyms: | (+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid | 2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid | 2-(2-fluorobiphenyl-4-yl)propanoic acid | 2-fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic acid | 3-fluoro-4-phenylhydratropic acid | Ansaid | CHEMBL563 | FLURBIPROFEN | US9630914, Compound A |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13FO2 |
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| Mol. Mass. | 244.2609 |
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| SMILES | CC(C(O)=O)c1ccc(c(F)c1)-c1ccccc1 |
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| Structure | 
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