Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50420801 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_839813 (CHEMBL2089824) |
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Ki | >400±n/a nM |
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Citation | Pedregal, C; Joshi, EM; Toledo, MA; Lafuente, C; Diaz, N; Martinez-Grau, MA; Jiménez, A; Benito, A; Navarro, A; Chen, Z; Mudra, DR; Kahl, SD; Rash, KS; Statnick, MA; Barth, VN Development of LC-MS/MS-based receptor occupancy tracers and positron emission tomography radioligands for the nociceptin/orphanin FQ (NOP) receptor. J Med Chem55:4955-67 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50420801 |
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n/a |
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Name | BDBM50420801 |
Synonyms: | CHEMBL2088035 |
Type | Small organic molecule |
Emp. Form. | C27H28N4O2 |
Mol. Mass. | 440.5368 |
SMILES | CNC(=O)Cn1c2ccccc2n(C2CCN(CC2)[C@@H]2Cc3cccc4cccc2c34)c1=O |r| |
Structure |
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