Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50421124 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_842489 (CHEMBL2092214) |
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Ki | 11±n/a nM |
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Citation | Fukaya, T; Kodo, T; Ishiyama, T; Kakuyama, H; Nishikawa, H; Baba, S; Masumoto, S Design, synthesis and structure-activity relationships of novel benzoxazolone derivatives as 18 kDa translocator protein (TSPO) ligands. Bioorg Med Chem20:5568-82 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50421124 |
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n/a |
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Name | BDBM50421124 |
Synonyms: | CHEMBL2088541 |
Type | Small organic molecule |
Emp. Form. | C21H17N3O3 |
Mol. Mass. | 359.378 |
SMILES | CN(C(=O)Cn1c2cc(ccc2oc1=O)-c1cccnc1)c1ccccc1 |
Structure |
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