| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase NRas |
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| Ligand | BDBM50421183 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_839699 (CHEMBL2089526) |
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| IC50 | 500±n/a nM |
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| Citation |  Wang, W; Fang, G; Rudolph, J Ras inhibition via direct Ras binding--is there a path forward? Bioorg Med Chem Lett22:5766-76 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| GTPase NRas |
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| Name: | GTPase NRas |
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| Synonyms: | HRAS1 | NRAS | RASN_HUMAN | Transforming protein N-Ras |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21223.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_839699 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDL
PTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQG
CMGLPCVVM
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| BDBM50421183 |
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| n/a |
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| Name | BDBM50421183 |
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| Synonyms: | CHEMBL2086789 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28N2O9S |
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| Mol. Mass. | 520.552 |
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| SMILES | OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)N(CCOc1ccc2ccccc2c1)S(=O)(=O)c1ccc(NO)cc1 |r| |
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| Structure | 
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