Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM79172 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_201132 (CHEMBL805753) |
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IC50 | 2.2±n/a nM |
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Citation | Myers, AM; Charifson, PS; Owens, CE; Kula, NS; McPhail, AT; Baldessarini, RJ; Booth, RG; Wyrick, SD Conformational analysis, pharmacophore identification, and comparative molecular field analysis of ligands for the neuromodulatory sigma 3 receptor. J Med Chem37:4109-17 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM79172 |
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n/a |
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Name | BDBM79172 |
Synonyms: | 2-[4-[(3Z)-3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol;hydrochloride | 2-[4-[(3Z)-3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol;hydrochloride | 2-[4-[(3Z)-3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazino]ethanol;hydrochloride | Fluphenthixol | MLS001332581 | SMR000875208 | cid_10140115 | cis-(Z)-Flupenthixol dihydrochloride |
Type | Small organic molecule |
Emp. Form. | C23H25F3N2OS |
Mol. Mass. | 434.518 |
SMILES | OCCN1CCN(CC\C=C2\c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1 |
Structure |
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