| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-H/Cyclin-dependent kinase 7 |
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| Ligand | BDBM50423760 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_612600 (CHEMBL1064250) |
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| Ki | 1200±n/a nM |
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| Citation |  McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM Design, synthesis, and evaluation of 2-methyl- and 2-amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as ring-constrained 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin-dependent kinase inhibitors. J Med Chem53:2136-45 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-H/Cyclin-dependent kinase 7 |
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| Name: | Cyclin-H/Cyclin-dependent kinase 7 |
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| Synonyms: | CDK-activating kinase assembly factor MAT1/Cyclin H/Cyclin-dependent kinase 7 | CDK7/Cyclin H | CDK7/H | Cyclin H/dependent kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7/ cyclin H | Cyclin-dependent kinase 7/cyclin H |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-H |
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| Synonyms: | CCNH | CCNH_HUMAN | Cyclin H | MO15-associated protein | p34 | p37 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 37646.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 323 |
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| Sequence: | MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYY
EKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNV
SSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPI
LENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKE
NRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDD
DYVSKKSKHEEEEWTDDDLVESL
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| Component 2 |
| Name: | Cyclin-dependent kinase 7 |
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| Synonyms: | 39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 39047.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 346 |
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| Sequence: | MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
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| BDBM50423760 |
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| n/a |
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| Name | BDBM50423760 |
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| Synonyms: | CHEMBL599804 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13N5S |
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| Mol. Mass. | 295.362 |
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| SMILES | Nc1nc2CCc3cnc(Nc4ccccc4)nc3-c2s1 |
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| Structure | 
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