Reaction Details |
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Target | Apoptosis regulator Bcl-2 |
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Ligand | BDBM50336585 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_934034 (CHEMBL2318341) |
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IC50 | 945±n/a nM |
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Citation | Song, T; Li, X; Chang, X; Liang, X; Zhao, Y; Wu, G; Xie, S; Su, P; Wu, Z; Feng, Y; Zhang, Z 3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1. Bioorg Med Chem21:11-20 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Apoptosis regulator Bcl-2 |
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Name: | Apoptosis regulator Bcl-2 |
Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
Type: | Homodimer or heterodimer |
Mol. Mass.: | 26269.11 |
Organism: | Homo sapiens (Human) |
Description: | P10415 |
Residue: | 239 |
Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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BDBM50336585 |
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n/a |
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Name | BDBM50336585 |
Synonyms: | 3-(4-methoxyphenylthio)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile | CHEMBL1672077 |
Type | Small organic molecule |
Emp. Form. | C22H12N2O2S |
Mol. Mass. | 368.408 |
SMILES | COc1ccc(Sc2ccc3c4c(C#N)c(=O)nc4c4cccc2c34)cc1 |
Structure |
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