Ki Summary

Reaction Details

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Target

Putative glycogen synthase kinase

Ligand

BDBM50424224

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_934472 (CHEMBL2321419)

IC50

>100000±n/a nM

Citation

Fugel, W; Oberholzer, AE; Gschloessl, B; Dzikowski, R; Pressburger, N; Preu, L; Pearl, LH; Baratte, B; Ratin, M; Okun, I; Doerig, C; Kruggel, S; Lemcke, T; Meijer, L; Kunick, C 3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3. J Med Chem56:264-75 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Putative glycogen synthase kinase

Name:

Putative glycogen synthase kinase

Synonyms:

GSK3

Type:

PROTEIN

Mol. Mass.:

40718.45

Organism:

Leishmania major

Description:

ChEMBL_934472

Residue:

355

Sequence:

MSLNAAAAADERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNR
ELQIMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVA
PPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPS
EPNVAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIV
RVLGCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEE
RMKPYEALCHPYFDELHDPATKLPNNKDLPEDLFRFLPNEIEVMSEAQKAKLVRK

BDBM50424224

n/a

Name

BDBM50424224

Synonyms:

CHEMBL2313850

Type

Small organic molecule

Emp. Form.

C21H12BrClN4OS

Mol. Mass.

483.768

SMILES

Nc1c(sc2nc(N)c(C#N)c(-c3ccccc3Br)c12)C(=O)c1cccc(Cl)c1 |(50.21,-49.5,;49.73,-50.97,;50.65,-52.22,;49.74,-53.48,;48.26,-53,;46.93,-53.77,;45.59,-53,;44.26,-53.77,;45.6,-51.45,;44.26,-50.67,;42.93,-49.9,;46.92,-50.68,;46.91,-49.15,;48.25,-48.38,;48.24,-46.84,;46.91,-46.07,;45.57,-46.85,;45.58,-48.39,;44.25,-49.17,;48.26,-51.45,;52.19,-52.22,;52.96,-50.89,;52.96,-53.56,;52.18,-54.89,;52.95,-56.22,;54.49,-56.22,;55.26,-54.88,;56.8,-54.87,;54.49,-53.55,)|

Structure