| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl-2-like protein 1 |
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| Ligand | BDBM50424731 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_934322 (CHEMBL2320308) |
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| Ki | 6800±n/a nM |
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| Citation |  Friberg, A; Vigil, D; Zhao, B; Daniels, RN; Burke, JP; Garcia-Barrantes, PM; Camper, D; Chauder, BA; Lee, T; Olejniczak, ET; Fesik, SW Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J Med Chem56:15-30 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl-2-like protein 1 |
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| Name: | Bcl-2-like protein 1 |
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| Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
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| Type: | Mitochondrion membrane; Single-pass membrane protein |
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| Mol. Mass.: | 26039.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 233 |
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| Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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| BDBM50424731 |
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| n/a |
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| Name | BDBM50424731 |
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| Synonyms: | CHEMBL2314210 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18ClNO3 |
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| Mol. Mass. | 379.836 |
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| SMILES | OC(=O)c1[nH]c2cc(Cl)ccc2c1CCCOc1cccc2ccccc12 |
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| Structure | 
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