| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
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| Ligand | BDBM50424737 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_934323 (CHEMBL2320309) |
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| Ki | 4300±n/a nM |
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| Citation |  Friberg, A; Vigil, D; Zhao, B; Daniels, RN; Burke, JP; Garcia-Barrantes, PM; Camper, D; Chauder, BA; Lee, T; Olejniczak, ET; Fesik, SW Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J Med Chem56:15-30 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Apoptosis regulator Bcl-2 |
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| Name: | Apoptosis regulator Bcl-2 |
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| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
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| Type: | Homodimer or heterodimer |
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| Mol. Mass.: | 26269.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10415 |
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| Residue: | 239 |
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| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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| BDBM50424737 |
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| n/a |
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| Name | BDBM50424737 |
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| Synonyms: | CHEMBL2314519 | US10093640, Example 21 | US10844032, Example 21 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18O4 |
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| Mol. Mass. | 346.3759 |
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| SMILES | OC(=O)c1oc2ccccc2c1CCCOc1cccc2ccccc12 |
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| Structure | 
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