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TargetIntermediate conductance calcium-activated potassium channel protein 4
LigandBDBM50425111
Substrate/Competitorn/a
Meas. Tech.ChEMBL_936631 (CHEMBL2319030)
IC50 500±n/a nM
Citation Olsson, RI; Jacobson, I; Boström, J; Fex, T; Björe, A; Olsson, C; Sundell, J; Gran, U; Öhrn, A; Nordin, A; Gyll, J; Thorstensson, M; Hayen, A; Aplander, K; Hidestål, O; Jiang, F; Linhardt, G; Forsström, E; Collins, T; Sundqvist, M; Lindhardt, E; Åstrand, A; Löfberg, B Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5. Bioorg Med Chem Lett23:706-10 (2013) [PubMed]  Article
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Intermediate conductance calcium-activated potassium channel protein 4
Name:Intermediate conductance calcium-activated potassium channel protein 4
Synonyms:IK1 | IKCA1 | KCA4 | KCNN4 | KCNN4_HUMAN | Putative Gardos channel | SK4
Type:PROTEIN
Mol. Mass.:47723.22
Organism:Homo sapiens (Human)
Description:ChEMBL_1361891
Residue:427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
EPSQQSK
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BDBM50425111
n/a
NameBDBM50425111
Synonyms:CHEMBL2312926 | Rac-3-((Diphenylphosphoryl)(Phenyl)Methyl)Pyridine
TypeSmall organic molecule
Emp. Form.C24H20NOP
Mol. Mass.369.3955
SMILESO=P(C(c1ccccc1)c1cccnc1)(c1ccccc1)c1ccccc1
Structure
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