| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA desaturase 1 |
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| Ligand | BDBM50425256 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_933806 (CHEMBL2321360) |
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| IC50 | 1.000000±n/a nM |
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| Citation |  Deng, Y; Yang, Z; Shipps, GW; Lo, SM; West, R; Hwa, J; Zheng, S; Farley, C; Lachowicz, J; van Heek, M; Bass, AS; Sinha, DP; Mahon, CR; Cartwright, ME Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1). Bioorg Med Chem Lett23:791-6 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA desaturase 1 |
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| Name: | Acyl-CoA desaturase 1 |
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| Synonyms: | ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41485.97 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P07308 |
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| Residue: | 358 |
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| Sequence: | MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQD
EEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHR
LWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSH
VGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGET
FLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYH
HAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
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| BDBM50425256 |
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| n/a |
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| Name | BDBM50425256 |
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| Synonyms: | CHEMBL2315179 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23F3N4OS |
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| Mol. Mass. | 484.537 |
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| SMILES | FC(F)(F)c1cccc(CN2CCC3(CCN(CC3)c3ncc(s3)C#N)Oc3ccccc23)c1 |
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| Structure | 
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