| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acyl-CoA desaturase 1 |
|---|
| Ligand | BDBM50425276 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_933806 (CHEMBL2321360) |
|---|
| IC50 | 380±n/a nM |
|---|
| Citation |  Deng, Y; Yang, Z; Shipps, GW; Lo, SM; West, R; Hwa, J; Zheng, S; Farley, C; Lachowicz, J; van Heek, M; Bass, AS; Sinha, DP; Mahon, CR; Cartwright, ME Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1). Bioorg Med Chem Lett23:791-6 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acyl-CoA desaturase 1 |
|---|
| Name: | Acyl-CoA desaturase 1 |
|---|
| Synonyms: | ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41485.97 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P07308 |
|---|
| Residue: | 358 |
|---|
| Sequence: | MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQD
EEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHR
LWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSH
VGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGET
FLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYH
HAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
|
|
|
|---|
| BDBM50425276 |
|---|
| n/a |
|---|
| Name | BDBM50425276 |
|---|
| Synonyms: | CHEMBL2315491 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H28F3N3O4 |
|---|
| Mol. Mass. | 527.5348 |
|---|
| SMILES | FC(F)(F)c1cccc(CC(=O)N2CCC3(CC2)CCN(CNC(=O)c2ccco2)c2ccccc2O3)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
