| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B1, mitochondrial |
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| Ligand | BDBM50425452 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_935760 (CHEMBL2321524) |
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| IC50 | 4.0±n/a nM |
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| Citation |  Yin, L; Hu, Q; Hartmann, RW Tetrahydropyrroloquinolinone type dual inhibitors of aromatase/aldosterone synthase as a novel strategy for breast cancer patients with elevated cardiovascular risks. J Med Chem56:460-70 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B1, mitochondrial |
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| Name: | Cytochrome P450 11B1, mitochondrial |
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| Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
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| Type: | Enzyme |
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| Mol. Mass.: | 57591.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15538 |
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| Residue: | 503 |
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| Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
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| BDBM50425452 |
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| n/a |
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| Name | BDBM50425452 |
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| Synonyms: | CHEMBL2312967 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18N2O |
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| Mol. Mass. | 278.3483 |
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| SMILES | CC(c1cccnc1)c1cc2CCN3c2c(CCC3=O)c1 |
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| Structure | 
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