| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-1A adrenergic receptor |
|---|
| Ligand | BDBM50122815 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_939354 (CHEMBL2327489) |
|---|
| Ki | 0.230000±n/a nM |
|---|
| Citation |  Jørgensen, M; Jørgensen, PN; Christoffersen, CT; Jensen, KG; Balle, T; Bang-Andersen, B Discovery of novela1-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligands. Bioorg Med Chem21:196-204 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Alpha-1A adrenergic receptor |
|---|
| Name: | Alpha-1A adrenergic receptor |
|---|
| Synonyms: | ADA1A_BOVIN | ADRA1A | ADRA1C | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha-1C adrenergic receptor | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 51492.08 |
|---|
| Organism: | CALF |
|---|
| Description: | adrenergic Alpha1 0 CALF |
|---|
| Residue: | 466 |
|---|
| Sequence: | MVFLSGNASDSSNCTHPPPPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNVWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
AQVGGSGVTSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FRPSETVFKIAFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHTLGYTL
HAPSHVLEGQHKDLVRIPVGSAETFYKISKTDGVCEWKIFSSLPRGSARMAVARDPSACT
TARVRSKSFLQVCCCLGPSTPSHGENHQIPTIKIHTISLSENGEEV
|
|
|
|---|
| BDBM50122815 |
|---|
| n/a |
|---|
| Name | BDBM50122815 |
|---|
| Synonyms: | 1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one | CHEMBL319352 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H29FN8O |
|---|
| Mol. Mass. | 488.5599 |
|---|
| SMILES | Cn1nnc(n1)-c1ccc2n(cc(C3CCN(CCN4CCNC4=O)CC3)c2c1)-c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
