| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin-like modifier-activating enzyme 7 |
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| Ligand | BDBM50427035 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_939702 (CHEMBL2328927) |
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| IC50 | 4000±n/a nM |
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| Citation |  da Silva, SR; Paiva, SL; Lukkarila, JL; Gunning, PT Exploring a new frontier in cancer treatment: targeting the ubiquitin and ubiquitin-like activating enzymes. J Med Chem56:2165-77 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin-like modifier-activating enzyme 7 |
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| Name: | Ubiquitin-like modifier-activating enzyme 7 |
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| Synonyms: | D8 | UBA7 | UBA7_HUMAN | UBE1L | UBE2 | Ubiquitin-activating enzyme 7 | Ubiquitin-activating enzyme E1 homolog |
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| Type: | PROTEIN |
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| Mol. Mass.: | 111679.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_939702 |
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| Residue: | 1012 |
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| Sequence: | MDALDASKLLDEELYSRQLYVLGSPAMQRIQGARVLVSGLQGLGAEVAKNLVLMGVGSLT
LHDPHPTCWSDLAAQFLLSEQDLERSRAEASQELLAQLNRAVQVVVHTGDITEDLLLDFQ
VVVLTAAKLEEQLKVGTLCHKHGVCFLAADTRGLVGQLFCDFGEDFTVQDPTEAEPLTAA
IQHISQGSPGILTLRKGANTHYFRDGDLVTFSGIEGMVELNDCDPRSIHVREDGSLEIGD
TTTFSRYLRGGAITEVKRPKTVRHKSLDTALLQPHVVAQSSQEVHHAHCLHQAFCALHKF
QHLHGRPPQPWDPVDAETVVGLARDLEPLKRTEEEPLEEPLDEALVRTVALSSAGVLSPM
VAMLGAVAAQEVLKAISRKFMPLDQWLYFDALDCLPEDGELLPSPEDCALRGSRYDGQIA
VFGAGFQEKLRRQHYLLVGAGAIGCELLKVFALVGLGAGNSGGLTVVDMDHIERSNLSRQ
FLFRSQDVGRPKAEVAAAAARGLNPDLQVIPLTYPLDPTTEHIYGDNFFSRVDGVAAALD
SFQARRYVAARCTHYLKPLLEAGTSGTWGSATVFMPHVTEAYRAPASAAASEDAPYPVCT
VRYFPSTAEHTLQWARHEFEELFRLSAETINHHQQAHTSLADMDEPQTLTLLKPVLGVLR
VRPQNWQDCVAWALGHWKLCFHYGIKQLLRHFPPNKVLEDGTPFWSGPKQCPQPLEFDTN
QDTHLLYVLAAANLYAQMHGLPGSQDWTALRELLKLLPQPDPQQMAPIFASNLELASASA
EFGPEQQKELNKALEVWSVGPPLKPLMFEKDDDSNFHVDFVVAAASLRCQNYGIPPVNRA
QSKRIVGQIIPAIATTTAAVAGLLGLELYKVVSGPRPRSAFRHSYLHLAENYLIRYMPFA
PAIQTFHHLKWTSWDRLKVPAGQPERTLESLLAHLQEQHGLRVRILLHGSALLYAAGWSP
EKQAQHLPLRVTELVQQLTGQAPAPGQRVLVLELSCEGDDEDTAFPPLHYEL
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| BDBM50427035 |
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| n/a |
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| Name | BDBM50427035 |
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| Synonyms: | CHEMBL2017005 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22N6O6S |
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| Mol. Mass. | 462.48 |
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| SMILES | NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N[C@H]3CCc4ccccc34)ncnc12 |r| |
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| Structure | 
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