Reaction Details |
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Target | NEDD8-activating enzyme E1 regulatory subunit |
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Ligand | BDBM50427035 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_939705 (CHEMBL2328930) |
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IC50 | 10.0±n/a nM |
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Citation | da Silva, SR; Paiva, SL; Lukkarila, JL; Gunning, PT Exploring a new frontier in cancer treatment: targeting the ubiquitin and ubiquitin-like activating enzymes. J Med Chem56:2165-77 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NEDD8-activating enzyme E1 regulatory subunit |
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Name: | NEDD8-activating enzyme E1 regulatory subunit |
Synonyms: | APP-BP1 | APPBP1 | Amyloid beta precursor protein-binding protein 1, 59 kDa | Amyloid protein-binding protein 1 | NAE1 | Proto-oncogene protein 1 | ULA1_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 60233.54 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_939705 |
Residue: | 534 |
Sequence: | MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTII
DGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFF
CRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNAL
EDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEK
EDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQ
TPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNH
VAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPD
NEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVH
EFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
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BDBM50427035 |
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n/a |
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Name | BDBM50427035 |
Synonyms: | CHEMBL2017005 |
Type | Small organic molecule |
Emp. Form. | C19H22N6O6S |
Mol. Mass. | 462.48 |
SMILES | NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N[C@H]3CCc4ccccc34)ncnc12 |r| |
Structure |
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