Reaction Details |
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Target | Muscarinic acetylcholine receptor M4 |
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Ligand | BDBM50428140 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_945483 (CHEMBL2343487) |
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EC50 | 15±n/a nM |
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Citation | Sumiyoshi, T; Enomoto, T; Takai, K; Takahashi, Y; Konishi, Y; Uruno, Y; Tojo, K; Suwa, A; Matsuda, H; Nakako, T; Sakai, M; Kitamura, A; Uematsu, Y; Kiyoshi, A Discovery of novel N-substituted oxindoles as selective m1 and m4 muscarinic acetylcholine receptors partial agonists. ACS Med Chem Lett4:244-8 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M4 |
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Name: | Muscarinic acetylcholine receptor M4 |
Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 53079.31 |
Organism: | Homo sapiens (Human) |
Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
Residue: | 479 |
Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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BDBM50428140 |
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n/a |
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Name | BDBM50428140 |
Synonyms: | CHEMBL2336056 |
Type | Small organic molecule |
Emp. Form. | C22H31N3O3 |
Mol. Mass. | 385.4998 |
SMILES | CCOC(=O)N1CCC(C)(CN2CC[C@@H](C2)N2C(=O)Cc3ccccc23)CC1 |r| |
Structure |
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