| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit rho-1 |
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| Ligand | BDBM50211642 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_946451 (CHEMBL2340048) |
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| IC50 | 2220±n/a nM |
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| Citation |  Gavande, N; Kim, HL; Doddareddy, MR; Johnston, GA; Chebib, M; Hanrahan, JR Design, Synthesis, and Pharmacological Evaluation of Fluorescent and Biotinylated Antagonists of?1 GABAC Receptors. ACS Med Chem Lett4:402-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-aminobutyric acid receptor subunit rho-1 |
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| Name: | Gamma-aminobutyric acid receptor subunit rho-1 |
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| Synonyms: | GABA receptor rho-1 subunit | GABA-C receptor | GABRR1 | GBRR1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55892.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1456653 |
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| Residue: | 479 |
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| Sequence: | MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPI
LRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTM
TLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRV
QPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTD
ERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSW
VSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVL
EYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKP
DRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
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| BDBM50211642 |
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| n/a |
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| Name | BDBM50211642 |
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| Synonyms: | CHEMBL397209 | Methyl(1,2,3,6-tetrahydropyridinium-4-yl)phosphinate | methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C6H12NO2P |
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| Mol. Mass. | 161.1387 |
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| SMILES | CP(O)(=O)C1=CCNCC1 |t:4| |
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| Structure | 
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