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TargetCarbonic anhydrase 12
LigandBDBM50346463
Substrate/Competitorn/a
Meas. Tech.ChEMBL_942151
Ki 5530±n/a nM
Citation Tuccinardi TBertini SGranchi COrtore GMacchia MMinutolo FMartinelli ASupuran CT Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors. Bioorg Med Chem 21:1511-5 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 12
Name:Carbonic anhydrase
Synonyms:CA-XII | Carbonate dehydratase XII | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:Enzyme
Mol. Mass.:39456.00
Organism:Homo sapiens (Human)
Description:Catalytic domain of human cloned isozyme was used in the assay
Residue:354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50346463
n/a
NameBDBM50346463
Synonyms:(E)-2-chloro-3'-fluoro-4,4'-dihydroxybiphenyl-3-carbaldehyde oxime | CHEMBL1782958
TypeSmall organic molecule
Emp. Form.C13H9ClFNO3
Mol. Mass.281.667
SMILESOc1ccc(cc1F)-c1ccc(O)c(CN=O)c1Cl
Structure
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