| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily D member 3 |
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| Ligand | BDBM50428594 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_945528 (CHEMBL2344005) |
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| IC50 | >33000±n/a nM |
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| Citation |  Giordanetto, F; Wållberg, A; Knerr, L; Selmi, N; Ullah, V; Thorstensson, F; Lindelöf, Å; Karlsson, S; Nikitidis, G; Llinas, A; Wang, QD; Lindqvist, A; Högberg, G; Lindhardt, E; Åstrand, A; Duker, G Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor. Bioorg Med Chem Lett23:119-24 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily D member 3 |
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| Name: | Potassium voltage-gated channel subfamily D member 3 |
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| Synonyms: | KCND3 | KCND3_HUMAN | Kv channel-interacting protein 2/Potassium voltage-gated channel subfamily D member 3 | Potassium voltage-gated channel subfamily D member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv4.3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73464.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1478652 |
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| Residue: | 655 |
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| Sequence: | MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLER
YPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAF
YGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTST
LALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVE
YLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKF
SRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWY
TIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRR
AQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLL
HCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHP
GLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDG
LRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSIASNVVKVSAL
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| BDBM50428594 |
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| n/a |
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| Name | BDBM50428594 |
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| Synonyms: | CHEMBL2337981 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H32Cl2N4O3 |
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| Mol. Mass. | 459.41 |
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| SMILES | CC(C)(C)NC(=O)NCCN1CCC(CO)(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 |
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| Structure | 
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