Reaction Details |
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Target | 5-hydroxytryptamine receptor 2C |
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Ligand | BDBM50021265 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_946127 (CHEMBL2343529) |
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EC50 | >1000000±n/a nM |
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Citation | Jensen, AA; Plath, N; Pedersen, MH; Isberg, V; Krall, J; Wellendorph, P; Stensbøl, TB; Gloriam, DE; Krogsgaard-Larsen, P; Frølund, B Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties. J Med Chem56:1211-27 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 2C |
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Name: | 5-hydroxytryptamine receptor 2C |
Synonyms: | 5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 51836.79 |
Organism: | Homo sapiens (Human) |
Description: | P28335 |
Residue: | 458 |
Sequence: | MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
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BDBM50021265 |
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n/a |
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Name | BDBM50021265 |
Synonyms: | (THAZ)5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-6-ium-3-olate | 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-6-ium-3-olate(THAZ) | CHEMBL309689 |
Type | Small organic molecule |
Emp. Form. | C7H10N2O2 |
Mol. Mass. | 154.1665 |
SMILES | O=c1[n-]oc2CC[NH2+]CCc12 |
Structure |
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