Reaction Details |
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Target | G-protein coupled bile acid receptor 1 |
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Ligand | BDBM50428101 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_943575 (CHEMBL2343388) |
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EC50 | 2.3±n/a nM |
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Citation | Londregan, AT; Piotrowski, DW; Futatsugi, K; Warmus, JS; Boehm, M; Carpino, PA; Chin, JE; Janssen, AM; Roush, NS; Buxton, J; Hinchey, T Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries. Bioorg Med Chem Lett23:1407-11 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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G-protein coupled bile acid receptor 1 |
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Name: | G-protein coupled bile acid receptor 1 |
Synonyms: | BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 35260.02 |
Organism: | Homo sapiens (Human) |
Description: | CHO cells transiently transfected with hTGR5. |
Residue: | 330 |
Sequence: | MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA
GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP
PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA
AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY
VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ
GLWGRASRDSPGPSIAYHPSSQSSVDLDLN
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BDBM50428101 |
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n/a |
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Name | BDBM50428101 |
Synonyms: | CHEMBL2331648 |
Type | Small organic molecule |
Emp. Form. | C20H22F3N5O3 |
Mol. Mass. | 437.4156 |
SMILES | CCNc1nc2CCN(Cc2c(n1)C(N)=O)C(=O)CCc1ccc(OC(F)(F)F)cc1 |
Structure |
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