| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acyl-CoA desaturase 1 |
|---|
| Ligand | BDBM50430000 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_945816 (CHEMBL2339163) |
|---|
| IC50 | 11800±n/a nM |
|---|
| Citation |  Matter, H; Zoller, G; Herling, AW; Sanchez-Arias, JA; Philippo, C; Namane, C; Kohlmann, M; Pfenninger, A; Voss, MD Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization. Bioorg Med Chem Lett23:1817-22 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acyl-CoA desaturase 1 |
|---|
| Name: | Acyl-CoA desaturase 1 |
|---|
| Synonyms: | ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41485.97 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P07308 |
|---|
| Residue: | 358 |
|---|
| Sequence: | MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQD
EEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHR
LWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSH
VGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGET
FLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYH
HAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
|
|
|
|---|
| BDBM50430000 |
|---|
| n/a |
|---|
| Name | BDBM50430000 |
|---|
| Synonyms: | CHEMBL2334651 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H20F3N3O2 |
|---|
| Mol. Mass. | 487.4725 |
|---|
| SMILES | FC(F)(F)c1cccc(CNC(=O)c2ccc3nc([nH]c3c2)-c2ccc(Oc3ccccc3)cc2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
