Reaction Details |
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Target | Sodium/iodide cotransporter |
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Ligand | BDBM50430690 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_942514 (CHEMBL2346169) |
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IC50 | 73±n/a nM |
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Citation | Lacotte, P; Buisson, DA; Ambroise, Y Synthesis, evaluation and absolute configuration assignment of novel dihydropyrimidin-2-ones as picomolar sodium iodide symporter inhibitors. Eur J Med Chem62:722-7 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium/iodide cotransporter |
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Name: | Sodium/iodide cotransporter |
Synonyms: | Na(+)/I(-) cotransporter | Na(+)/I(-) symporter | Nis | SC5A5_RAT | Slc5a5 | Sodium-iodide symporter | Solute carrier family 5 member 5 |
Type: | PROTEIN |
Mol. Mass.: | 65197.60 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_942514 |
Residue: | 618 |
Sequence: | MEGAEAGARATFGAWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVG
LSLAASFMSAVQVLGVPAEAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTSTYQY
LELRFSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTT
VGGMKAVVWTDVFQVVVMLVGFWVILARGVILLGGPRNVLSLAQNHSRINLMDFDPDPRS
RYTFWTFIVGGTLVWLSMYGVNQAQVQRYVACHTEGKAKLALLVNQLGLFLIVASAACCG
IVMFVYYKDCDPLLTGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSIN
AMAAVTVEDLIKPRMPGLAPRKLVFISKGLSFIYGSACLTVAALSSLLGGGVLQGSFTVM
GVISGPLLGAFTLGMLLPACNTPGVLSGLAAGLAVSLWVAVGATLYPPGEQTMGVLPTSA
AGCTNDSVLLGPPGATNASNGIPSSGMDTGRPALADTFYAISYLYYGALGTLTTMLCGAL
ISYLTGPTKRSSLGPGLLWWDLARQTASVAPKEDTATLEESLVKGPEDIPAVTKKPPGLK
PGAETHPLYLGHDVETNL
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BDBM50430690 |
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n/a |
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Name | BDBM50430690 |
Synonyms: | CHEMBL2333503 |
Type | Small organic molecule |
Emp. Form. | C19H18N2O6 |
Mol. Mass. | 370.356 |
SMILES | CN1C(=O)NC(c2ccco2)C(C(=O)OCc2ccc3OCOc3c2)=C1C |c:27| |
Structure |
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