| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/iodide cotransporter |
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| Ligand | BDBM50430698 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_942514 (CHEMBL2346169) |
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| IC50 | 1.6±n/a nM |
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| Citation |  Lacotte, P; Buisson, DA; Ambroise, Y Synthesis, evaluation and absolute configuration assignment of novel dihydropyrimidin-2-ones as picomolar sodium iodide symporter inhibitors. Eur J Med Chem62:722-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/iodide cotransporter |
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| Name: | Sodium/iodide cotransporter |
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| Synonyms: | Na(+)/I(-) cotransporter | Na(+)/I(-) symporter | Nis | SC5A5_RAT | Slc5a5 | Sodium-iodide symporter | Solute carrier family 5 member 5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65197.60 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_942514 |
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| Residue: | 618 |
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| Sequence: | MEGAEAGARATFGAWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVG
LSLAASFMSAVQVLGVPAEAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTSTYQY
LELRFSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTT
VGGMKAVVWTDVFQVVVMLVGFWVILARGVILLGGPRNVLSLAQNHSRINLMDFDPDPRS
RYTFWTFIVGGTLVWLSMYGVNQAQVQRYVACHTEGKAKLALLVNQLGLFLIVASAACCG
IVMFVYYKDCDPLLTGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSIN
AMAAVTVEDLIKPRMPGLAPRKLVFISKGLSFIYGSACLTVAALSSLLGGGVLQGSFTVM
GVISGPLLGAFTLGMLLPACNTPGVLSGLAAGLAVSLWVAVGATLYPPGEQTMGVLPTSA
AGCTNDSVLLGPPGATNASNGIPSSGMDTGRPALADTFYAISYLYYGALGTLTTMLCGAL
ISYLTGPTKRSSLGPGLLWWDLARQTASVAPKEDTATLEESLVKGPEDIPAVTKKPPGLK
PGAETHPLYLGHDVETNL
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| BDBM50430698 |
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| n/a |
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| Name | BDBM50430698 |
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| Synonyms: | CHEMBL2333513 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N2O5 |
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| Mol. Mass. | 370.3991 |
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| SMILES | COc1ccc(COC(=O)C2=C(C)N(C)C(=O)N(C)C2c2ccco2)cc1 |c:10| |
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| Structure | 
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