Reaction Details |
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Target | Sodium/iodide cotransporter |
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Ligand | BDBM50430686 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_942514 (CHEMBL2346169) |
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IC50 | 89±n/a nM |
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Citation | Lacotte, P; Buisson, DA; Ambroise, Y Synthesis, evaluation and absolute configuration assignment of novel dihydropyrimidin-2-ones as picomolar sodium iodide symporter inhibitors. Eur J Med Chem62:722-7 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium/iodide cotransporter |
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Name: | Sodium/iodide cotransporter |
Synonyms: | Na(+)/I(-) cotransporter | Na(+)/I(-) symporter | Nis | SC5A5_RAT | Slc5a5 | Sodium-iodide symporter | Solute carrier family 5 member 5 |
Type: | PROTEIN |
Mol. Mass.: | 65197.60 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_942514 |
Residue: | 618 |
Sequence: | MEGAEAGARATFGAWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVG
LSLAASFMSAVQVLGVPAEAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTSTYQY
LELRFSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTT
VGGMKAVVWTDVFQVVVMLVGFWVILARGVILLGGPRNVLSLAQNHSRINLMDFDPDPRS
RYTFWTFIVGGTLVWLSMYGVNQAQVQRYVACHTEGKAKLALLVNQLGLFLIVASAACCG
IVMFVYYKDCDPLLTGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSIN
AMAAVTVEDLIKPRMPGLAPRKLVFISKGLSFIYGSACLTVAALSSLLGGGVLQGSFTVM
GVISGPLLGAFTLGMLLPACNTPGVLSGLAAGLAVSLWVAVGATLYPPGEQTMGVLPTSA
AGCTNDSVLLGPPGATNASNGIPSSGMDTGRPALADTFYAISYLYYGALGTLTTMLCGAL
ISYLTGPTKRSSLGPGLLWWDLARQTASVAPKEDTATLEESLVKGPEDIPAVTKKPPGLK
PGAETHPLYLGHDVETNL
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BDBM50430686 |
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n/a |
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Name | BDBM50430686 |
Synonyms: | CHEMBL2333506 |
Type | Small organic molecule |
Emp. Form. | C20H20N2O4 |
Mol. Mass. | 352.3838 |
SMILES | COc1ccc(COC(=O)C2[C@@H](NC(=O)N=C2C)c2ccccc2)cc1 |r,c:15| |
Structure |
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