| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-1 adrenergic receptor |
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| Ligand | BDBM50174271 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_949262 (CHEMBL2346138) |
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| Ki | 68±n/a nM |
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| Citation |  Stevens, BD Structure-based fragment screening is demonstrated to be a practical lead discovery method for a representative G-protein-coupled receptor. J Med Chem56:3444-5 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-1 adrenergic receptor |
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| Name: | Beta-1 adrenergic receptor |
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| Synonyms: | ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 51338.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08588 |
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| Residue: | 477 |
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| Sequence: | MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
FFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGP
PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
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| BDBM50174271 |
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| n/a |
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| Name | BDBM50174271 |
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| Synonyms: | 4-(piperazin-1-yl)-1H-indole | CHEMBL200234 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H15N3 |
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| Mol. Mass. | 201.2676 |
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| SMILES | C1CN(CCN1)c1cccc2[nH]ccc12 |
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| Structure | 
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