| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Heparanase |
|---|
| Ligand | BDBM50041457 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_950896 (CHEMBL2349720) |
|---|
| Kd | 52600±n/a nM |
|---|
| Citation |  Gozalbes, R; Mosulén, S; Ortí, L; Rodríguez-Díaz, J; Carbajo, RJ; Melnyk, P; Pineda-Lucena, A Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches. Bioorg Med Chem21:1944-51 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Heparanase |
|---|
| Name: | Heparanase |
|---|
| Synonyms: | Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE | HPSE1 | HPSE_HUMAN | HSE1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Heparanase-1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 61167.67 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_327900 |
|---|
| Residue: | 543 |
|---|
| Sequence: | MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVT
IDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQS
QVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCS
GLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGS
QLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYL
NGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFA
AGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLM
ASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLL
RPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVA
ACI
|
|
|
|---|
| BDBM50041457 |
|---|
| n/a |
|---|
| Name | BDBM50041457 |
|---|
| Synonyms: | 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol | AMODIAQUINE | CHEMBL682 | med.21724, Compound 188 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H22ClN3O |
|---|
| Mol. Mass. | 355.861 |
|---|
| SMILES | CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O |
|---|
| Structure | 
|
|---|
Search and Browse
