| Reaction Details |
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 | Report a problem with these data |
| Target | Heparanase |
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| Ligand | BDBM50175813 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_950897 (CHEMBL2349721) |
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| IC50 | 290±n/a nM |
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| Citation |  Gozalbes, R; Mosulén, S; Ortí, L; Rodríguez-Díaz, J; Carbajo, RJ; Melnyk, P; Pineda-Lucena, A Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches. Bioorg Med Chem21:1944-51 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heparanase |
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| Name: | Heparanase |
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| Synonyms: | Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE | HPSE1 | HPSE_HUMAN | HSE1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Heparanase-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61167.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_327900 |
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| Residue: | 543 |
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| Sequence: | MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVT
IDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQS
QVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCS
GLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGS
QLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYL
NGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFA
AGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLM
ASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLL
RPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVA
ACI
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| BDBM50175813 |
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| n/a |
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| Name | BDBM50175813 |
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| Synonyms: | CHEMBL200831 | N-(4-{[5-(1H-benzoimidazol-2-yl)-pyridin-2-ylamino]methyl}-phenyl)-3-bromo-4-methoxy-benzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C27H22BrN5O2 |
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| Mol. Mass. | 528.4 |
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| SMILES | COc1ccc(cc1Br)C(=O)Nc1ccc(CNc2ccc(cn2)-c2nc3ccccc3[nH]2)cc1 |
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| Structure | 
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