Reaction Details |
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Target | Corticotropin-releasing factor receptor 1 |
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Ligand | BDBM50432107 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_950616 (CHEMBL2352366) |
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IC50 | 7.4±n/a nM |
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Citation | Denhart, DJ; Zuev, D; Ditta, JL; Hartz, RA; Ahuja, VT; Mattson, RJ; Huang, H; Mattson, GK; Zueva, L; Nielsen, JM; Kozlowski, ES; Lodge, NJ; Bronson, JJ; Macor, JE Potential CRF1R PET imaging agents: 1-fluoroalkylsubstituted 5-halo-3-(arylamino)pyrazin-2(1H)-ones. Bioorg Med Chem Lett23:2052-5 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Corticotropin-releasing factor receptor 1 |
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Name: | Corticotropin-releasing factor receptor 1 |
Synonyms: | CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 47870.75 |
Organism: | Rattus norvegicus (rat) |
Description: | Receptor binding assays were performed using rat cortex homogenate. |
Residue: | 415 |
Sequence: | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEV
HQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPF
PIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
VFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
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BDBM50432107 |
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n/a |
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Name | BDBM50432107 |
Synonyms: | CHEMBL2349565 |
Type | Small organic molecule |
Emp. Form. | C20H22ClFN4O2 |
Mol. Mass. | 404.866 |
SMILES | Cc1cc(cc(C)c1Nc1nc(Cl)cn([C@@H](COCCF)C2CC2)c1=O)C#N |r| |
Structure |
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