Reaction Details |
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Target | Sodium-dependent serotonin transporter |
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Ligand | BDBM50432299 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_951590 (CHEMBL2351265) |
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IC50 | 26±n/a nM |
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Citation | Wu, YJ; He, H; Bertekap, R; Westphal, R; Lelas, S; Newton, A; Wallace, T; Taber, M; Davis, C; Macor, JE; Bronson, J Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression. Bioorg Med Chem21:2217-28 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent serotonin transporter |
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Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70322.51 |
Organism: | Homo sapiens (Human) |
Description: | P31645 |
Residue: | 630 |
Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
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BDBM50432299 |
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n/a |
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Name | BDBM50432299 |
Synonyms: | CHEMBL2347854 |
Type | Small organic molecule |
Emp. Form. | C23H25F6NO |
Mol. Mass. | 445.4411 |
SMILES | CN1CCC[C@@](COCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)(CC1)c1ccccc1 |r| |
Structure |
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