Reaction Details |
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Target | Myeloperoxidase |
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Ligand | BDBM50432573 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_950696 (CHEMBL2352939) |
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IC50 | 6.0±n/a nM |
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Citation | Soubhye, J; Aldib, I; Elfving, B; Gelbcke, M; Furtmüller, PG; Podrecca, M; Conotte, R; Colet, JM; Rousseau, A; Reye, F; Sarakbi, A; Vanhaeverbeek, M; Kauffmann, JM; Obinger, C; Nève, J; Prévost, M; Zouaoui Boudjeltia, K; Dufrasne, F; Van Antwerpen, P Design, synthesis, and structure-activity relationship studies of novel 3-alkylindole derivatives as selective and highly potent myeloperoxidase inhibitors. J Med Chem56:3943-58 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Myeloperoxidase |
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Name: | Myeloperoxidase |
Synonyms: | 84 kDa myeloperoxidase | 89 kDa myeloperoxidase | MPO | Mpo protein | Myeloperoxidase | Myeloperoxidase (MPO) | Myeloperoxidase heavy chain | Myeloperoxidase light chain | PERM_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 83888.32 |
Organism: | Homo sapiens (Human) |
Description: | P05164 |
Residue: | 745 |
Sequence: | MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS
LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH
VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC
NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD
QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND
PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL
GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL
REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR
SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE
GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN
AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL
LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS
NSYPRDFVNCSTLPALNLASWREAS
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BDBM50432573 |
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n/a |
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Name | BDBM50432573 |
Synonyms: | CHEMBL2347170 |
Type | Small organic molecule |
Emp. Form. | C12H15FN2S |
Mol. Mass. | 238.324 |
SMILES | NCCSCCc1c[nH]c2c(F)cccc12 |
Structure |
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