| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-S-isoprenylcysteine O-methyltransferase |
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| Ligand | BDBM50433090 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_956034 (CHEMBL2380129) |
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| IC50 | 2560±n/a nM |
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| Citation |  Ramanujulu, PM; Yang, T; Yap, SQ; Wong, FC; Casey, PJ; Wang, M; Go, ML Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). Eur J Med Chem63:378-86 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-S-isoprenylcysteine O-methyltransferase |
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| Name: | Protein-S-isoprenylcysteine O-methyltransferase |
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| Synonyms: | ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31943.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_956034 |
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| Residue: | 284 |
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| Sequence: | MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
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| BDBM50433090 |
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| n/a |
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| Name | BDBM50433090 |
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| Synonyms: | CHEMBL2376426 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H37FN2 |
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| Mol. Mass. | 408.5945 |
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| SMILES | CCCCCCCCn1cc(CN(CC)CC)c2cc(ccc12)-c1ccccc1F |
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| Structure | 
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