| Reaction Details |
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 | Report a problem with these data |
| Target | Transcriptional activator Myb |
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| Ligand | BDBM50433429 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_958516 (CHEMBL2383288) |
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| IC50 | 15849±n/a nM |
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| Citation |  Schomburg, C; Schuehly, W; Da Costa, FB; Klempnauer, KH; Schmidt, TJ Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships. Eur J Med Chem63:313-20 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcriptional activator Myb |
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| Name: | Transcriptional activator Myb |
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| Synonyms: | MYB | MYB_CHICK | Proto-oncogene c-Myb |
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| Type: | PROTEIN |
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| Mol. Mass.: | 72474.34 |
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| Organism: | Gallus gallus |
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| Description: | ChEMBL_107588 |
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| Residue: | 641 |
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| Sequence: | MARRPRHSIYSSDDDEEDVEMYDHDYDGLLPKAGKRHLGKTRWTREEDEKLKKLVEQNGT
EDWKVIASFLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK
HLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA
IKNHWNSTMRRKVEQEGYLQESSKAGLPSATTGFQKSSHLMAFAHNPPAGPLPGAGQAPL
GSDYPYYHIAEPQNVPGQIPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELEL
LLMSTENELKGQQALPTQNHTANYPGWHSTTVADNTRTSGDNAPVSCLGEHHHCTPSPPV
DHGCLPEESASPARCMIVHQSNILDNVKNLLEFAETLQLIDSFLNTSSNHENLNLDNPAL
TSTPVCGHKMSVTTPFHRDQPFKTQKENHVFRTPAIKRSILESSPRTPTPFKNALAAQEI
KYGPLKMLPQTPTHLVEDLQDVIKQESEESAIVAGLHESGPPLLKKIKQEVESPTDKAGN
FFCSNHWEGENLNTQLFTHASTMEDVPNLLTSSILKMPVSEEEGSFHKAFAVPRNRPLAS
PMQHLNNAWESASCGKTEDQMALTDQARKYMAAFPTRTLVM
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| BDBM50433429 |
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| n/a |
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| Name | BDBM50433429 |
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| Synonyms: | ROTUNDIN |
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| Type | Small organic molecule |
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| Emp. Form. | C22H28O8 |
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| Mol. Mass. | 420.4529 |
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| SMILES | C\C=C(\C)C(=O)O[C@@H]1C[C@@]2(COC(C)=O)O[C@@H]2C[C@H](O)\C(C)=C/[C@H]2OC(=O)C(=C)[C@H]12 |r,c:22| |
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| Structure | 
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