| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-7 |
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| Ligand | BDBM50433565 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_959892 (CHEMBL2383618) |
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| Ki | 29500±n/a nM |
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| Citation |  Faundez-Parraguez, M; Farias-Rabelo, N; Gonzalez-Gutierrez, JP; Etcheverry-Berrios, A; Alzate-Morales, J; Adasme-Carreño, F; Varas, R; Bermudez, I; Iturriaga-Vasquez, P Neonicotinic analogues: selective antagonists fora4ß2 nicotinic acetylcholine receptors. Bioorg Med Chem21:2687-94 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-7 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-7 |
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| Synonyms: | ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR) |
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| Type: | n/a |
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| Mol. Mass.: | 56448.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | CHRNA7 (NACHRA7) |
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| Residue: | 502 |
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| Sequence: | MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL
QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK
QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL
LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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| BDBM50433565 |
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| n/a |
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| Name | BDBM50433565 |
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| Synonyms: | CHEMBL2381567 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22N2O3 |
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| Mol. Mass. | 326.3896 |
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| SMILES | CN1CCC[C@H]1COC(=O)c1ccc(OCc2ccccc2)nc1 |r| |
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| Structure | 
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