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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Insulin-like growth factor 1 receptor | ||
| Ligand | BDBM50433761 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_959958 (CHEMBL2383900) | ||
| IC50 | 12000±n/a nM | ||
| Citation |  Meng, Z; Ciavarri, JP; McRiner, A; Zhao, Y; Zhao, L; Reddy, PA; Zhang, X; Fischmann, TO; Whitehurst, C; Arshad Siddiqui, M Potency switch between CHK1 and MK2: discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors. Bioorg Med Chem Lett23:2863-7 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Insulin-like growth factor 1 receptor | |||
| Name: | Insulin-like growth factor 1 receptor | ||
| Synonyms: | CD_antigen=CD221 | IGF-I receptor | IGF1R | IGF1R_HUMAN | Insulin-like growth factor 1 receptor (IGF1R) | Insulin-like growth factor 1 receptor (IGFIR) | Insulin-like growth factor 1 receptor alpha chain | Insulin-like growth factor 1 receptor beta chain | Insulin-like growth factor I receptor | Insulin-like growth factor receptor (IGFR) | ||
| Type: | Protein | ||
| Mol. Mass.: | 154776.79 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08069 | ||
| Residue: | 1367 | ||
| Sequence: |
| ||
| BDBM50433761 | |||
| n/a | |||
| Name | BDBM50433761 | ||
| Synonyms: | CHEMBL2381601 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H21ClN6O | ||
| Mol. Mass. | 384.863 | ||
| SMILES | N[C@H]1CC[C@@H](CC1)Nc1ncc(C(N)=O)n2cc(nc12)-c1ccc(Cl)cc1 |r,wU:4.7,wD:1.0,(5.4,-11.59,;6.74,-12.36,;6.74,-13.9,;8.07,-14.67,;9.41,-13.9,;9.4,-12.36,;8.07,-11.59,;10.74,-14.67,;10.75,-16.21,;9.42,-16.98,;9.42,-18.52,;10.75,-19.29,;10.75,-20.83,;9.42,-21.6,;12.09,-21.6,;12.09,-18.51,;13.56,-18.98,;14.46,-17.73,;13.55,-16.49,;12.08,-16.97,;16,-17.72,;16.77,-19.05,;18.31,-19.04,;19.07,-17.7,;20.61,-17.69,;18.29,-16.37,;16.75,-16.38,)| | ||
| Structure | 
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