Reaction Details | |||
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Target | Serine/threonine-protein kinase Chk1 | ||
Ligand | BDBM50433761 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_959964 (CHEMBL2383906) | ||
IC50 | 1080±n/a nM | ||
Citation | Meng, Z; Ciavarri, JP; McRiner, A; Zhao, Y; Zhao, L; Reddy, PA; Zhang, X; Fischmann, TO; Whitehurst, C; Arshad Siddiqui, M Potency switch between CHK1 and MK2: discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors. Bioorg Med Chem Lett23:2863-7 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase Chk1 | |||
Name: | Serine/threonine-protein kinase Chk1 | ||
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 54443.02 | ||
Organism: | Homo sapiens (Human) | ||
Description: | gi_166295192 | ||
Residue: | 476 | ||
Sequence: |
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BDBM50433761 | |||
n/a | |||
Name | BDBM50433761 | ||
Synonyms: | CHEMBL2381601 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H21ClN6O | ||
Mol. Mass. | 384.863 | ||
SMILES | N[C@H]1CC[C@@H](CC1)Nc1ncc(C(N)=O)n2cc(nc12)-c1ccc(Cl)cc1 |r,wU:4.7,wD:1.0,(5.4,-11.59,;6.74,-12.36,;6.74,-13.9,;8.07,-14.67,;9.41,-13.9,;9.4,-12.36,;8.07,-11.59,;10.74,-14.67,;10.75,-16.21,;9.42,-16.98,;9.42,-18.52,;10.75,-19.29,;10.75,-20.83,;9.42,-21.6,;12.09,-21.6,;12.09,-18.51,;13.56,-18.98,;14.46,-17.73,;13.55,-16.49,;12.08,-16.97,;16,-17.72,;16.77,-19.05,;18.31,-19.04,;19.07,-17.7,;20.61,-17.69,;18.29,-16.37,;16.75,-16.38,)| | ||
Structure |