| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 7 |
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| Ligand | BDBM50434069 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_958415 (CHEMBL2382797) |
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| EC50 | >30000±n/a nM |
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| Citation |  Elkins, JM; Wang, J; Deng, X; Pattison, MJ; Arthur, JS; Erazo, T; Gomez, N; Lizcano, JM; Gray, NS; Knapp, S X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor. J Med Chem56:4413-21 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 7 |
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| Name: | Mitogen-activated protein kinase 7 |
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| Synonyms: | BMK1 | Big MAP kinase 1 | ERK5 | Extracellular signal-regulated kinase 5 (ERK5) | MAPK7 | MK07_HUMAN | PRKM7 |
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| Type: | Protein |
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| Mol. Mass.: | 88377.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13164 |
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| Residue: | 816 |
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| Sequence: | MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIET
IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDI
LRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIH
RDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT
QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQS
LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCA
PPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMP
SPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALK
AALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERER
KERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPV
QPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATS
TSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKS
QVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLAD
WLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
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| BDBM50434069 |
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| n/a |
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| Name | BDBM50434069 |
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| Synonyms: | CHEMBL2381339 | US9676792, Compound 24 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H38N8O3 |
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| Mol. Mass. | 582.6959 |
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| SMILES | COc1cc(ccc1Nc1ncc2N(C)C(=O)c3cccc4CCN(c34)c2n1)C(=O)N1CCC(CC1)N1CCN(C)CC1 |
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| Structure | 
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