| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 8 |
|---|
| Ligand | BDBM50434137 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_958945 (CHEMBL2382523) |
|---|
| EC50 | 4300±n/a nM |
|---|
| Citation |  Monn, JA; Valli, MJ; Massey, SM; Hao, J; Reinhard, MR; Bures, MG; Heinz, BA; Wang, X; Carter, JH; Getman, BG; Stephenson, GA; Herin, M; Catlow, JT; Swanson, S; Johnson, BG; McKinzie, DL; Henry, SS Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists. J Med Chem56:4442-55 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metabotropic glutamate receptor 8 |
|---|
| Name: | Metabotropic glutamate receptor 8 |
|---|
| Synonyms: | GPRC1H | GRM8 | GRM8_HUMAN | MGLUR8 | Metabotropic glutamate receptor 8 | metabotropic glutamate 8 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 101759.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | metabotropic glutamate 8 GRM8 HUMAN::O00222 |
|---|
| Residue: | 908 |
|---|
| Sequence: | MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER
GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV
QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA
PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR
EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA
EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN
KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER
CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF
VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC
FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH
IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA
KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI
IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTY
ISYSNHSI
|
|
|
|---|
| BDBM50434137 |
|---|
| n/a |
|---|
| Name | BDBM50434137 |
|---|
| Synonyms: | CHEMBL2381649 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H14N2O5 |
|---|
| Mol. Mass. | 242.2286 |
|---|
| SMILES | CC(=O)N[C@H]1C[C@](N)([C@H]2[C@@H]1[C@@H]2C(O)=O)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
