| Reaction Details |
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 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily V member 6 |
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| Ligand | BDBM50434547 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_962122 (CHEMBL2388391) |
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| IC50 | 14200±n/a nM |
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| Citation |  Hofer, A; Kovacs, G; Zappatini, A; Leuenberger, M; Hediger, MA; Lochner, M Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. Bioorg Med Chem21:3202-13 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transient receptor potential cation channel subfamily V member 6 |
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| Name: | Transient receptor potential cation channel subfamily V member 6 |
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| Synonyms: | CaT-L | CaT-like | CaT1 | Calcium transport protein 1 | ECAC2 | Epithelial calcium channel 2 | TRPV6 | TRPV6_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 87295.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_103784 |
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| Residue: | 765 |
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| Sequence: | MGPLQGDGGPALGGADVAPRLSPVRVWPRPQAPKEPALHPMGLSLPKEKGLILCLWSKFC
RWFQRRESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGE
TALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVVNQNMNLVRALLARR
ASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVL
HILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLM
QKRKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLK
WKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQEAYMTP
KDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTILGGPFHVLIITYAFMVLVTM
VMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVV
ILGFASAFYIIFQTEDPEELGHFYDYPMALFSTFELFLTIIDGPANYNVDLPFMYSITYA
AFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVATTVMLERKLPRCLWPRSGICG
REYGLGDRWFLRVEDRQDLNRQRIQRYAQAFHTRGSEDLDKDSVEKLELGCPFSPHLSLP
MPSVSRSTSRSSANWERLRQGTLRRDLRGIINRGLEDGESWEYQI
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| BDBM50434547 |
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| n/a |
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| Name | BDBM50434547 |
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| Synonyms: | CHEMBL2386174 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14BF2NO |
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| Mol. Mass. | 261.075 |
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| SMILES | Fc1ccc(cc1)[B-]1([NH2+]CCO1)c1ccc(F)cc1 |
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| Structure | 
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