| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-acyl carrier reductase ENR |
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| Ligand | BDBM50435717 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_965386 (CHEMBL2394873) |
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| IC50 | 19±n/a nM |
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| Citation |  Muench, SP; Stec, J; Zhou, Y; Afanador, GA; McPhillie, MJ; Hickman, MR; Lee, PJ; Leed, SE; Auschwitz, JM; Prigge, ST; Rice, DW; McLeod, R Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides. Bioorg Med Chem Lett23:3551-5 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Enoyl-acyl carrier reductase ENR |
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| Name: | Enoyl-acyl carrier reductase ENR |
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| Synonyms: | Enoyl-acyl carrier reductase | Enoyl-acyl carrier reductase (ENR) | Enoyl-acyl carrier reductase, putative |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43663.67 |
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| Organism: | Toxoplasma gondii |
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| Description: | ChEMBL_1290812 |
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| Residue: | 417 |
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| Sequence: | MVGFKLLTLGAFVAGELTLVGPAGTMAFTVPNATGAKPLVTSVSVRPSWSSARQNAFSSS
SSRSQSSVRPHSAFVTNRLETAGETGTQHRAADSAAGVGAAQSAFPIDLRGQTAFVAGVA
DSHGYGWAIAKHLASAGARVALGTWPPVLGLFQKSLQSGRLDEDRKLPDGSLIEFAGVYP
LDAAFDKPEDVPQDIKDNKRYAGVDGYTIKEVAVKVKQDLGNIDILVHSLANGPEVTKPL
LETSRKGYLAASSNSAYSFVSLLQHFGPIMNEGGSAVTLSYLAAERVVPGYGGGMSSAKA
ALESDTRTLAWEAGQKYGVRVNAISAGPLKSRAASAIGKSGEKSFIDYAIDYSYNNAPLR
RDLHSDDVGGAALFLLSPLARAVSGVTLYVDNGLHAMGQAVDSRSMPPLQRATQEIN
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| BDBM50435717 |
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| n/a |
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| Name | BDBM50435717 |
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| Synonyms: | CHEMBL2392450 | N‐{[4‐(2,4‐dichlorophenoxy)‐3‐ hydroxyphenyl]methyl}‐5‐methyl‐1,2‐oxazole‐3‐ carboxamide (27) |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14Cl2N2O4 |
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| Mol. Mass. | 393.221 |
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| SMILES | Cc1cc(no1)C(=O)NCc1ccc(Oc2ccc(Cl)cc2Cl)c(O)c1 |
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| Structure | 
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