| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-3 |
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| Ligand | BDBM50435965 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_964097 (CHEMBL2394604) |
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| IC50 | >500000±n/a nM |
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| Citation |  Limpachayaporn, P; Riemann, B; Kopka, K; Schober, O; Schäfers, M; Haufe, G Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7. Eur J Med Chem64:562-78 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-3 |
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| Name: | Caspase-3 |
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| Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
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| Type: | Hydrolase; heterotetramer of two heterodimers |
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| Mol. Mass.: | 31607.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 277 |
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| Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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| BDBM50435965 |
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| n/a |
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| Name | BDBM50435965 |
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| Synonyms: | CHEMBL2391979 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H20N2O6S |
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| Mol. Mass. | 368.405 |
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| SMILES | COC[C@@H]1CC[C@@H](COC)N1S(=O)(=O)c1ccc2NC(=O)C(=O)c2c1 |r| |
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| Structure | 
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