| Reaction Details |
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 | Report a problem with these data |
| Target | Growth factor receptor-bound protein 2 |
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| Ligand | BDBM50436052 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_968023 (CHEMBL2401275) |
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| IC50 | 5700000±n/a nM |
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| Citation |  Simister, PC; Luccarelli, J; Thompson, S; Appella, DH; Feller, SM; Hamilton, AD Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen. Bioorg Med Chem21:4027-33 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth factor receptor-bound protein 2 |
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| Name: | Growth factor receptor-bound protein 2 |
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| Synonyms: | ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2 |
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| Type: | Protein |
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| Mol. Mass.: | 25205.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P62993 |
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| Residue: | 217 |
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| Sequence: | MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
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| BDBM50436052 |
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| n/a |
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| Name | BDBM50436052 |
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| Synonyms: | CHEMBL2396934 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28N6 |
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| Mol. Mass. | 364.4872 |
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| SMILES | CC1(C)N=C(N)N=C(N)N1c1cccc(CCCCc2cccc(N)c2)c1 |t:3,6| |
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| Structure | 
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